Extracellular matrix (ECM) is a major component of the cell microenvironment with important signaling and regulatory functions. Derived from healthy acellular porcine lung, TissueSpec® lung matrix is rich in basement membrane proteins including collagen IV and laminins, sulfated glycosaminoglycans (e.g., heparin sulfate), and structural collagen I and elastin fibers that provide crucial biomechanical signaling for pulmonary airway and alveolar cell types.

TissueSpec® Lung Scaffolds supported enhanced proliferation, expression of alveolar epithelial cell markers, and re-uptake of surfactant by lung stem cells.