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by Tissue Type by Application

Cartilage ECM cell culture substrates

Extracellular matrix (ECM) is a major component of the cell microenvironment with important signaling and regulatory functions. Derived from healthy acellular porcine hyaline cartilage, TissueSpec® cartilage matrix is rich in type II collagen with fibrous proteins, proteoglycans, hyaluronic acid (HA), and chondroitin sulfate that together regulate chondrogenesis, chondrocyte differentiation, response to mechanical stimulation, matrix remodeling, metabolism, and survival and provide biomechanical signals through cell-matrix interactions.

TissueSpec® Cartilage Hydrogels supported the chondrogenic differentiation of mesenchymal stem cells, which formed cartilageous tissue constructs and demonstrated increased mechanical stiffness and biochemical properties resembling native articular cartilage.

Item: MTSCT201
NativeCoat™ ECM Surface Coating 
Instructions Datasheet
Item: MTSCT300 TissueSpec® ECM Scaffold (custom) Datasheet

 

Available Lines

Item #Product Name
MTSCT201 NativeCoat™ Cartilage ECM Surface Coating MTSCT201 NativeCoat™ Cartilage ECM Surface Coating Applications Instructions Datasheet


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Custom Matrix Formats

TissueSpec® ECM scaffolds are available through custom order. Xylyx Bio also specializes in isolating extracellular matrix from additional tissues or specific regions within tissues of interest as well as other sources (e.g., human).

Related Resources

Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials. (2018)
Constrained cage culture improves engineered cartilage functional properties by enhancing collagen network stability. Tissue Eng Part A. (2017)

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Choose your tissue-specific ECM substrate based on the tissue and organ of origin.

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